William A. Pailes
- Status: Retired
- In Space: No
- Date of Birth: 06/26/1952
- First Flight: 10/03/1985
- Last Flight: 10/03/1985
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William A. Pailes, a American astronaut affiliated with the payload specialist agency United States Air Force, embarked on 1 space flights and engaging in 0 spacewalks during his/her career as an astronaut.
William Arthur Pailes (Colonel, USAF) (born June 26, 1952) was a USAF astronaut in the Manned Spaceflight Engineer Program during the mid-1980s. He served as a Payload Specialist on STS-51-J Atlantis (October 3–7, 1985).