Yuzhnoye Design Bureau – OKB-586
- Type: Commercial
- Abbreviation: OKB-586
- Administration: Director: Alexander Degtyarev
- Founded: 1951
- Launchers: Zenit
- Country: UKR
Yuzhnoye Design Office, located in Dnipro, Ukraine, is a designer of satellites and rockets, and formerly of Soviet intercontinental ballistic missiles (ICBMs) established by Mikhail Yangel in 1951. The Zenit launch vehicle currently launches from Baikonur Cosmodrome but also used to launch from an ocean platform, Odyssey.